| Year | Name | Team/Organization |
| 1987 | Glenn Warren | San Francisco Giants |
| 1988 | Ray Martinez | Oakland A's |
| 1990 | Steve Mintz | Los Angeles Dodgers |
| 1993 | Dennis Stutts | Montreal Expos |
| 1995 | Chris Bray | Baltimore Orioles |
| 1995 | Bobby Cooke | St. Louis Cardinals |
| 1997 | Curtis Whitley | Chicago White Sox |
| 1999 | Brian Morse | Florida Marlins |
| 1999 | Scott McKee | Montreal Expos |
| 2000 | Michael Wiggs | Pittsburgh Pirates |
| 2004 | Craig Hurba | Texas Rangers/Seattle Mariners |
| 2004 | Josh Clow | Kansas City Royals |
| 2005 | Matt Rusch | Detroit Tigers |
| 2006 | Justin Staatz | Minnesota Twins |
| 2007 | Tom Layne | Boston Red Sox (Drafted by Arizona Diamondbacks, traded to San Diego Padres in 2012, signed with Red Sox after 2013 season) |
| 2007 | Scott Houin | Milwaukee Brewers |
| 2008 | David Cooper | Arizona Diamondbacks |
| 2008 | Casey Hodges | Atlanta Braves |
| 2008 | Erik Lovett | New York Yankees |
| 2008 | Ryan Schlecht | Texas Rangers |
| 2008 | Michael Williams | Pittsburgh Pirates |
| 2009 | Rich Racobaldo | St. Louis Cardinals |
| 2010 | Jeremy Nowak | Baltimore Orioles |
| 2010 | Ryan Kussmaul | Chicago White Sox |
| 2011 | Michael Knox | St. Louis Cardinals |
| 2011 | Carter Capps | San Diego(drafted in 3rd round by Seattle Mariners - highest pick in school history, traded to Marlins prior to 2014 season, traded to Padres in 2017) |
| 2011 | Pete Levitt | Chicago Cubs |
| 2012 | Jacob Rogers | Chicago Cubs |
| 2012 | Antonio Callaway | Canberra Cavalry (Australia) |
| 2013 | Geno Escalante | San Francisco Giants |
| 2013 | Mike Mercurio | Kansas City Royals |
| 2014 | Jay Gonzalez | Baltimore Orioles |
| 2014 | Deshorn Lake | New York Yankees |
| 2015 | Jason Morozowski | Arizona Diamondbacks |
| 2015 | Hunter Barnett | Toronto Blue Jays |
| 2015 | Gunnar Kines | Miami Marlins |
| 2017 | Bruce Zimmerman | Atlanta Braves |
| 2017 | Ricky Surum | New York Yankees |
| 2017 | Zack Mozingo | Tampa Bay Rays |
| 2017 | Austin Hutchison | Seattle Mariners |
| 2017 | Kodi Whitley* | St. Louis Cardinals |
*Currently playing in Major League
Click Bolded links to active MLB/MILB professional players